| http://purl.uniprot.org/citations/18511424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18511424 | http://www.w3.org/2000/01/rdf-schema#comment | "Secreted phospholipase A2 group X (sPLA(2)-X) is one of the most potent enzymes of the phospholipase A(2) lipolytic enzyme superfamily. Its high catalytic activity toward phosphatidylcholine (PC), the major phospholipid of cell membranes and low-density lipoproteins (LDL), has implicated sPLA(2)-X in chronic inflammatory conditions such as atherogenesis. We studied the role of sPLA(2)-X enzyme activity in vitro and in vivo, by generating sPLA(2)-X-overexpressing macrophages and transgenic macrophage-specific sPLA(2)-X mice. Our results show that sPLA(2)-X expression inhibits macrophage activation and inflammatory responses upon stimulation, characterized by reduced cell adhesion and nitric oxide production, a decrease in tumor necrosis factor (TNF), and an increase in interleukin (IL)-10. These effects were mediated by an increase in IL-6, and enhanced production of prostaglandin E(2) (PGE(2)) and 15-deoxy-Delta12,14-prostaglandin J(2) (PGJ(2)). Moreover, we found that overexpression of active sPLA(2)-X in macrophages strongly increases foam cell formation upon incubation with native LDL but also oxidized LDL (oxLDL), which is mediated by enhanced expression of scavenger receptor CD36. Transgenic sPLA(2)-X mice died neonatally because of severe lung pathology characterized by interstitial pneumonia with massive granulocyte and surfactant-laden macrophage infiltration. We conclude that overexpression of the active sPLA(2)-X enzyme results in enhanced foam cell formation but reduced activation and inflammatory responses in macrophages in vitro. Interestingly, enhanced sPLA(2)-X activity in macrophages in vivo leads to fatal pulmonary defects, suggesting a crucial role for sPLA(2)-X in inflammatory lung disease."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m710584200"xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "Hofker M.H."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "Greaves D.R."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "Gijbels M.J."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "Vergouwe M.N."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "Verbeek J.S."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "van der Made I."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "de Winther M.P."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "Curfs D.M."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/author | "Ghesquiere S.A."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/pages | "21640-21648"xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/title | "Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology."xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18511424 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18511424 |
| http://purl.uniprot.org/citations/18511424 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18511424 |
| http://purl.uniprot.org/uniprot/O15496#attribution-07C09EFD2FC297AFA2A7B1BAF3518F11 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18511424 |
| http://purl.uniprot.org/uniprot/O15496#attribution-36093FD5A3695E6F9330E1955EDC8491 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18511424 |
| http://purl.uniprot.org/uniprot/O15496#attribution-89C2C3A5986C2490727BCA6C9AF63B3E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18511424 |
| http://purl.uniprot.org/uniprot/#_L8E7V2-mappedCitation-18511424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18511424 |
| http://purl.uniprot.org/uniprot/#_O15496-mappedCitation-18511424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18511424 |
| http://purl.uniprot.org/uniprot/#_Q8K130-mappedCitation-18511424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18511424 |