| http://purl.uniprot.org/citations/18511561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18511561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18511561 | http://www.w3.org/2000/01/rdf-schema#comment | "NOD2, a NOD-like receptor (NLR), is an intracellular sensor of bacterial muramyl dipeptide (MDP) that was suggested to promote secretion of the proinflammatory cytokine IL-1beta. Yet, the molecular mechanism by which NOD2 can stimulate IL-1beta secretion, and its biological significance were heretofore unknown. We found that NOD2 through its N-terminal caspase recruitment domain directly binds and activates caspase-1 to trigger IL-1beta processing and secretion in MDP-stimulated macrophages, whereas the C-terminal leucine-rich repeats of NOD2 prevent caspase-1 activation in nonstimulated cells. MDP challenge induces the association of NOD2 with another NLR protein, NALP1, and gel filtration analysis revealed the formation of a complex consisting of NOD2, NALP1, and caspase-1. Importantly, Bacillus anthracis infection induces IL-1beta secretion in a manner that depended on caspase-1 and NOD2. In vitro, Anthrax lethal toxin strongly potentiated IL-1beta secretion, and that response was NOD2 and caspase-1-dependent. Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0802726105"xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0802726105"xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Hsu L.C."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Hsu L.C."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Nizet V."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Nizet V."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Mariathasan S."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Mariathasan S."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Ali S.R."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Ali S.R."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Humke E.W."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Humke E.W."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Eckmann L."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Eckmann L."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "McGillivray S."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "McGillivray S."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Powell J.J."xsd:string |
| http://purl.uniprot.org/citations/18511561 | http://purl.uniprot.org/core/author | "Powell J.J."xsd:string |