| http://purl.uniprot.org/citations/18511904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18511904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18511904 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucocorticoids are widely used anti-inflammatory and immunomodulatory agents, of which the action mechanism is mainly based on interference of hormone-activated glucocorticoid receptor (GR) with the activity of transcription factors, such as nuclear factor-kappaB (NF-kappaB). In addition to the well described interaction-based mutual repression mechanism between the GR and NF-kappaB, additional mechanisms are at play, which help to explain the efficacy of glucocorticoid-mediated gene repression. In this respect, we found that glucocorticoids counteract the recruitment of activated Mitogen- and Stress-activated protein Kinase-1 (MSK1) at inflammatory gene promoters resulting in the inhibition of NF-kappaB p65 transactivation and of concurrent histone H3 phosphorylation. Additionally, we observed that activated GR can trigger redistribution of nuclear MSK1 to the cytoplasm through a CRM1-dependent export mechanism, as a result of an interaction between liganded GR and activated MSK1. These findings unveil a novel aspect within the GR-mediated NF-kappaB-targeting anti-inflammatory mechanism."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.95"xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.95"xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Haegeman G."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Haegeman G."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "De Bosscher K."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "De Bosscher K."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Beck I.M."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Beck I.M."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Bougarne N."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Bougarne N."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Vanden Berghe W."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Vanden Berghe W."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Vander Cruyssen B."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Vander Cruyssen B."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Vermeulen L."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/author | "Vermeulen L."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/pages | "1682-1693"xsd:string |
| http://purl.uniprot.org/citations/18511904 | http://purl.uniprot.org/core/pages | "1682-1693"xsd:string |