| http://purl.uniprot.org/citations/18512733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18512733 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormalities in neural connections and the neurotransmitter system appear to be involved in the pathophysiology of schizophrenia. The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, which consists of Syntaxin1A, vesicle-associated membrane protein 2 (VAMP2) and synaptosomal-associated protein 25 kDa (SNAP25), plays an important role in the neurotransmitter system, and is therefore an attractive place to search for candidate genes for schizophrenia. We conducted a two-stage genetic association analysis of Syntaxin1A (STX1A), VAMP2 and SNAP25 genes with schizophrenia (first-set screening samples: 377 cases and 377 controls, second-set confirmation samples: 657 cases and 527 controls). Based on the linkage disequilibrium, 40 SNPs (STX1A, 8 SNPs; VAMP2, 3 SNPs; SNAP25, 29 SNPs) were selected as 'tagging SNPs'. Only nominally significant associations of an SNP (rs12626080) and haplotype (rs363014 and rs12626080) in SNAP25 were detected in the first-set screening scan. To validate this significance, we carried out a replication analysis of these SNP and haplotype associations in second-set samples with a denser set of markers (including five additional SNPs). However, these associations could not be confirmed in the second-set analysis. These results suggest that the SNARE complex-related genes do not play a major role in susceptibility to schizophrenia in the Japanese population."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.org/dc/terms/identifier | "doi:10.1002/ajmg.b.30781"xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Ikeda M."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Inada T."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Kawashima K."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Takeda M."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Takahashi N."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Saito S."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Kitajima T."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Ozaki N."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Iwata N."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Hashimoto R."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Yamanouchi Y."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Yasuda Y."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Kishi T."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Kinoshita Y."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/author | "Ohi K."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/name | "Am J Med Genet B Neuropsychiatr Genet"xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/pages | "1327-1331"xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/title | "No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population."xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://purl.uniprot.org/core/volume | "147B"xsd:string |
| http://purl.uniprot.org/citations/18512733 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18512733 |
| http://purl.uniprot.org/citations/18512733 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18512733 |