http://purl.uniprot.org/citations/18517045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18517045 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveThere is a close association between narcolepsy and the human leukocyte antigen (HLA)-DQB1*0602. The detailed influence and function of this specific HLA allele with regard to narcolepsy have not yet been elucidated. Our previous report identified the myxovirus resistance 2 (MX2) gene as a narcolepsy-specific dysregulated gene; however, the report had a limitation-the control groups were not HLA matched. In this study, we examined the possibility of an association between MX2 expression and HLA haplotypes.DesignsThe expression levels of the MX2 gene in 3 groups (24 narcolepsy with cataplexy patients; 24 age-, sex-, and HLA-DQB1 genotype-matched controls; and 24 age- and sex-matched controls without the HLA-DQB1*0602 allele) were measured by quantitative real-time RT-PCR.ResultsThe expression level of the MX2 gene tended to be downregulated in subjects carrying HLA-DQB1*0602, compared with that of the control subjects without this allele. There was no difference in the MX2 expression level between the narcolepsy subjects and the HLA-DQB1 genotype-matched control subjects.ConclusionOur previous finding-the narcolepsy-specific reduction of MX2 gene expression-was not replicated in this follow-up study. The expression level of the MX2 gene in white blood cells was found to be lower in subjects with the HLA-DQB1*0602 than in subjects without this allele, suggesting that there exists a relationship between the HLA-DQB1*0602 allele and MX2 gene expression. This might be a possible explanation for the strong HLA association observed in narcolepsy."xsd:string |
http://purl.uniprot.org/citations/18517045 | http://purl.org/dc/terms/identifier | "doi:10.1093/sleep/31.5.749"xsd:string |
http://purl.uniprot.org/citations/18517045 | http://purl.uniprot.org/core/author | "Honda M."xsd:string |
http://purl.uniprot.org/citations/18517045 | http://purl.uniprot.org/core/author | "Tanaka S."xsd:string |
http://purl.uniprot.org/citations/18517045 | http://purl.uniprot.org/core/author | "Honda Y."xsd:string |
http://purl.uniprot.org/citations/18517045 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
http://purl.uniprot.org/citations/18517045 | http://purl.uniprot.org/core/name | "Sleep"xsd:string |
http://purl.uniprot.org/citations/18517045 | http://purl.uniprot.org/core/pages | "749-751"xsd:string |
http://purl.uniprot.org/citations/18517045 | http://purl.uniprot.org/core/title | "MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602."xsd:string |
http://purl.uniprot.org/citations/18517045 | http://purl.uniprot.org/core/volume | "31"xsd:string |
http://purl.uniprot.org/citations/18517045 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18517045 |
http://purl.uniprot.org/citations/18517045 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18517045 |
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http://purl.uniprot.org/uniprot/#_Q75MY8-mappedCitation-18517045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18517045 |
http://purl.uniprot.org/uniprot/#_P20592-mappedCitation-18517045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18517045 |
http://purl.uniprot.org/uniprot/Q75MY7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18517045 |
http://purl.uniprot.org/uniprot/P20592 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18517045 |
http://purl.uniprot.org/uniprot/Q75MY8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18517045 |