| http://purl.uniprot.org/citations/18519685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18519685 | http://www.w3.org/2000/01/rdf-schema#comment | "Tight junctions have recently emerged as essential signaling regulators of proliferation and differentiation in epithelial tissues. Here, we aimed to identify the factors regulating claudin-7 expression in the colon, and analyzed the consequences of claudin-7 overexpression in colorectal carcinoma (CRC). In healthy human colonic crypts, claudin-7 expression was found to be low in the stem/progenitor cell compartment, where Tcf-4 activity is high, but strong in differentiated and postmitotic cells, where Tcf-4 is inactive. In contrast, claudin-7 was overexpressed in areas with high Tcf-4 target gene levels in CRC samples. In vitro, Tcf-4 was able to repress claudin-7 expression, and the high mobility group-box transcription factor Sox-9 was identified as an essential mediator of this effect. Claudin-7 was strongly expressed in the intestine of Sox-9-deficient mice and in CRC cells with low Sox transcriptional activity. Sox-9 overexpression in these cells reinstated claudin-7 repression, and residual claudin-7 was no longer localized along the basolateral membrane, but was instead restricted to tight junctions. Using HT-29Cl.16E CRC cell spheroids, we found that Sox-9-induced polarization was completely reversed after virus-mediated claudin-7 overexpression. Claudin-7 overexpression in this context increased Tcf-4 target gene expression, proliferation, and tumorigenicity after injection in nude mice. Our results indicate that Tcf-4 maintains low levels of claudin-7 at the bottom of colonic crypts, acting via Sox-9. This negative regulation seems to be defective in CRC, possibly due to decreased Sox-9 activity, and the resulting claudin-7 overexpression promotes a loss of tumor cell polarization and contributes to tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-5805"xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Blache P."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Jay P."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Mantamadiotis T."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Darido C."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Buchert M."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Hollande F."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Joubert D."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Pannequin J."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Bastide P."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Bourgaux J.F."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Garambois V."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/author | "Zalzali H."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/pages | "4258-4268"xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/title | "Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells."xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/18519685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18519685 |
| http://purl.uniprot.org/citations/18519685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18519685 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-18519685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18519685 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-18519685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18519685 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTR9-mappedCitation-18519685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18519685 |