| http://purl.uniprot.org/citations/18519804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18519804 | http://www.w3.org/2000/01/rdf-schema#comment | "Sydney Brenner promoted Caenorhabditis elegans as a model organism, and subsequent investigations pursued resistance to the nicotinic anthelmintic drug levamisole in C. elegans at a genetic level. These studies have advanced our understanding of genes associated with neuromuscular transmission and resistance to the antinematodal drug. In lev-8 and lev-1 mutant C. elegans, levamisole resistance is associated with reductions in levamisole-activated whole muscle cell currents. Although lev-8 and lev-1 are known to code for nicotinic acetylcholine receptor (nAChR) subunits, an explanation for why these currents get smaller is not available. In wild-type adults, nAChRs aggregate at neuromuscular junctions and are not accessible for single-channel recording. Here we describe a use of LEV-10 knockouts, in which aggregation is lost, to make in situ recordings of nAChR channel currents. Our observations provide an explanation for levamisole resistance produced by LEV-8 and LEV-1 mutants at the single-channel level."xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.08-110502"xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/author | "Qian H."xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/author | "Powell-Coffman J.A."xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/author | "Martin R.J."xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/author | "Robertson A.P."xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/pages | "3247-3254"xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/title | "Levamisole resistance resolved at the single-channel level in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/18519804 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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