| http://purl.uniprot.org/citations/18519813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18519813 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently demonstrated that the 3-kb 5'-flanking region of the human ROBO4 gene directs endothelial cell-specific expression in vitro and in vivo. Moreover, a GA-binding protein (GABP)-binding motif at -119 was necessary for mediating promoter activity in vitro. The goal of the present study was to confirm the functional relevance of the -119 GABP-binding site in vivo. To that end, the Hprt locus of mice was targeted with a Robo4-LacZ transgenic cassette in which the GABP site was mutated. In other studies, the GABP mutation was introduced into the endogenous mouse Robo4 locus in which LacZ was knocked-in. Compared with their respective controls, the mutant promoters displayed a significant reduction in activity in embryoid bodies, embryos, and adult animals. Together, these data provide strong support for the role of the GABP-binding motif in mediating Robo4 expression in the intact endothelium."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-01-135079"xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Kitayama M."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Okada Y."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Yano K."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Doi T."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Oettgen P."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Minami T."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Jin E."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Aird W.C."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Spokes K."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Funahashi N."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Janes L."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Beeler D."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/author | "Nikolova-Krstevski V."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/pages | "2336-2339"xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/title | "A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo."xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18519813 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18519813 |
| http://purl.uniprot.org/citations/18519813 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18519813 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J197-mappedCitation-18519813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18519813 |