| http://purl.uniprot.org/citations/18521822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18521822 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation of the canonical Wnt signaling pathway protects hippocampal neurons against the toxicity of Alzheimer's amyloid-beta-peptide (Abeta), however, the role played by the Wnt receptors Frizzleds, has not been studied. We report here that Frizzled-1 mediates the activation of the canonical Wnt/beta-catenin pathway by Wnt3a in PC12 cells. In addition, the protective effect of Wnt3a against the toxicity of Abeta oligomers was modulated by Frizzled-1 expression levels in both PC12 cells and hippocampal neurons. Over-expression of Frizzled-1 significantly increased cell survival induced by Wnt3a and diminished caspase-3 activation, while knocking-down Frizzled-1 expression by antisense oligonucleotides decreased the Wnt3a protection. Over-expression of wild-type beta-catenin, but not a transcriptionally inactive mutated version, prevented the toxicity of Abeta suggesting that the transcription of Wnt target genes may be involved in these events. This was confirmed by co-transfecting both Frizzled-1 and the inactive form of beta-catenin, which does not elicited protection levels similar to those showed with endogenous beta-catenin. Our results indicate that Wnt3a protects from Abeta-oligomers toxicity by activating the canonical Wnt signaling pathway through the Frizzled-1 receptor, suggesting a therapeutic potential for this signaling pathway in the treatment of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.21497"xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://purl.uniprot.org/core/author | "Inestrosa N.C."xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://purl.uniprot.org/core/author | "Chacon M.A."xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://purl.uniprot.org/core/author | "Varela-Nallar L."xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18521822 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://purl.uniprot.org/core/pages | "215-227"xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://purl.uniprot.org/core/title | "Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers."xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://purl.uniprot.org/core/volume | "217"xsd:string |
| http://purl.uniprot.org/citations/18521822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18521822 |
| http://purl.uniprot.org/citations/18521822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18521822 |
| http://purl.uniprot.org/uniprot/#_A6K268-mappedCitation-18521822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18521822 |
| http://purl.uniprot.org/uniprot/#_A6HF01-mappedCitation-18521822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18521822 |
| http://purl.uniprot.org/uniprot/#_Q08463-mappedCitation-18521822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18521822 |
| http://purl.uniprot.org/uniprot/Q08463 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18521822 |
| http://purl.uniprot.org/uniprot/A6K268 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18521822 |
| http://purl.uniprot.org/uniprot/A6HF01 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18521822 |