| http://purl.uniprot.org/citations/18522869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18522869 | http://www.w3.org/2000/01/rdf-schema#comment | "Polymorphisms in the cytokine genes are known to influence cytokine levels and may be associated with outcome of infections. We investigated the polymorphisms in the cytokine genes namely IFN-gamma (+874 and +5644), IL-2 (-330 and +160), IL-4 (VNTR), IL-6 (-174), IL-10 (-1082 and -819) and IL-12B (+1188) in 188 normal healthy subjects (NHS) and 166 pulmonary tuberculosis patients (PTB) using polymerase chain reaction-based methods. To study the influence of cytokine gene polymorphisms on cytokine levels, phytohaemagglutinin and culture filtrate antigen of Mycobacterium tuberculosis-induced cytokine levels were measured by ELISA from 72-h-old peripheral blood mononuclear cell culture supernatants. Significantly decreased frequency of TT genotype of IL-2 -330 polymorphism (p=0.024, odds ratio (OR) 0.53, 95% CI 0.31-0.92) was observed in patients compared to NHS. The genotype frequencies of other polymorphisms were not different between patients and NHS. IL-12p40 levels were significantly decreased among NHS with AA genotype of IL-12B gene polymorphism compared to NHS with AC genotype (p<0.05). Increased levels of IL-12p40 were observed among patients with CC genotype of IL-12B gene compared to patients with other genotypes (p<0.01). The present study suggests that the TT genotype of IL-2 -330 polymorphism may be associated with the protection to PTB in south India. Further, +1188 polymorphism of IL-12B gene either alone or in combination with closely linked genes may regulate IL-12p40 production and may play a major role on acquired immunity to tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2008.04.011"xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/author | "Narayanan P.R."xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/author | "Selvaraj P."xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/author | "Harishankar M."xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/author | "Alagarasu K."xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/author | "Vidyarani M."xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/author | "Nisha Rajeswari D."xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/pages | "26-33"xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/title | "Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/18522869 | http://purl.uniprot.org/core/volume | "43"xsd:string |
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