| http://purl.uniprot.org/citations/18523273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18523273 | http://www.w3.org/2000/01/rdf-schema#comment | "During an acute immune response, CD8 T cells undergo rapid expansion followed by a contraction phase during which the majority of activated T cells die, leaving a few survivors to persist as memory cells. The regulation of T cell survival is critical at each stage of this response. 4-1BB, a TNFR family member, has been implicated in prolonging the survival of activated and memory CD8 T cells; however, the precise mechanisms by which 4-1BB sustains T cell survival are incompletely understood. Upon aggregation on T cells, 4-1BB associates with two TNFR-associated factors (TRAF), TRAF1 and TRAF2. TRAF2 is essential for downstream signaling from 4-1BB; however, the role of TRAF1 in 4-1BB signaling has not been elucidated and there have been conflicting data as to whether TRAF1 provides a positive or a negative signal in T cells. In this study, we report that TRAF1 plays a critical role in survival signaling downstream of 4-1BB during CD8 T cell expansion in response to viral infection in vivo. Further analysis reveals that TRAF1-deficient cells are impaired in their ability to up-regulate the prosurvival Bcl-2 family member Bcl-x(L) and show increased levels of the proapoptotic Bcl-2 family member Bim following 4-1BB signaling. TRAF1-deficient CD8 T cells fail to activate ERK in response to 4-1BB ligation and inhibition of ERK signaling downstream of 4-1BB in wild-type cells leads to increased Bim levels. Thus, TRAF1 has a prosurvival effect in CD8 T cells via the 4-1BB-mediated up-regulation of Bcl-x(L) and ERK-dependent Bim down-modulation."xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.12.8093"xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/author | "Tsitsikov E.N."xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/author | "Watts T.H."xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/author | "Sabbagh L."xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/author | "Pulle G."xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/pages | "8093-8101"xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/title | "ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo."xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18523273 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18523273 |
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