| http://purl.uniprot.org/citations/18523307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18523307 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation of Ag-specific T cells locally in the CNS could potentially contribute to the development of immune-mediated brain diseases. We addressed whether Ag-specific T cells could be stimulated in the CNS in the absence of peripheral lymphoid tissues by analyzing Ag-specific T cell responses in organotypic brain slice cultures. Organotypic brain slice cultures were established 1 h after intracerebral OVA Ag microinjection. We showed that when OVA-specific CD8(+) T cells were added to Ag-containing brain slices, these cells became activated and migrated into the brain to the sites of their specific Ags. This activation of OVA-specific T cells was abrogated by the deletion of CD11c(+) cells from the brain slices of the donor mice. These data suggest that brain-resident CD11c(+) cells stimulate Ag-specific naive CD8(+) T cells locally in the CNS and may contribute to immune responses in the brain."xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.12.8393"xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/author | "Sandor M."xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/author | "Ling C."xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/author | "Banks M.I."xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/author | "Fabry Z."xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/author | "Verbny Y.I."xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/pages | "8393-8399"xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/title | "In situ activation of antigen-specific CD8+ T cells in the presence of antigen in organotypic brain slices."xsd:string |
| http://purl.uniprot.org/citations/18523307 | http://purl.uniprot.org/core/volume | "180"xsd:string |
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