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http://purl.uniprot.org/citations/18523354http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18523354http://www.w3.org/2000/01/rdf-schema#comment"

Background

Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte antigen (HLA) class-II alleles or haplotypes.

Objectives

The present study was undertaken to determine the frequency of HLA class-II alleles in Iranian healthy adult responders and non-responders to HB vaccine.

Methods

Twelve non-responders (anti-HBs antibody<10 IU/L) and 46 responders (anti-HBs antibody>100 IU/L) were tissue typed for HLA class-II. HLA-DRB1, DQB1 and DQA1 alleles were determined using polymerase chain reaction based on sequence specific primers (PCR-SSP) technique. Accessibility to excess amount of genomic DNA was possible using Epstein-Barr virus (EBV)-transformed B-cells established from all vaccinees.

Results

Our results demonstrated increased frequencies of HLA-DRB107, DRB103, DRB104, DQB10201, DQA10201 alleles and HLA-DRB107/DQB10201/DQA10201 and DRB104/DQB10302/DQA103011 haplotypes in the non-responder group. Comparison between responders and non-responders revealed only a significant difference for DQB10201 allele (p<0.05).

Conclusion

These findings confirm the association of certain HLA alleles and haplotypes with the lack of antibody response to HB vaccine in an Iranian population."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/author"Amirzargar A.A."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/author"Shokri F."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/author"Ahmadi N."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/author"Shokrgozar M.A."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/author"Arjang Z."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/author"Amanzadeh A."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/author"Mohseni N."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/author"Yousefi Behzadi M."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/name"Iran J Immunol"xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/pages"92-99"xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/title"HLA-DRB1, DQA1 and DQB1 alleles and haplotypes frequencies in Iranian healthy adult responders and non-responders to recombinant hepatitis B vaccine."xsd:string
http://purl.uniprot.org/citations/18523354http://purl.uniprot.org/core/volume"5"xsd:string
http://purl.uniprot.org/citations/18523354http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18523354
http://purl.uniprot.org/citations/18523354http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18523354
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http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-18523354http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18523354
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http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-18523354http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18523354
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