| http://purl.uniprot.org/citations/18534576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18534576 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies showed that CD151-null mice have a skin wound healing deficit. To gain an understanding of the role of CD151 in re-epithelialisation and dermal contraction, keratinocyte and fibroblast functions were assayed. Primary CD151-null keratinocytes displayed defective migration on Matrigel (a basement membrane equivalent) and laminin-332, the primary adhesion component of basement membranes, but not on collagen-I. Adhesion, spreading and proliferation were also deficient on laminin-332, but not collagen-I. The data suggest that loss of CD151 impairs the function of its primary interaction partners, integrin alpha3beta1-and/or alpha6beta4 which bind to laminin-332. Skin fibroblasts also produce CD151 mRNA. CD151-null fibroblasts migrated significantly faster on collagen I than wild type fibroblasts, confirming that they possess functional collagen receptors. However, no significant decrease in the ability of CD151-null fibroblasts to cause contraction in floating collagen gel assays in response to transforming growth factor beta-1 (TGF-beta1) or platelet derived growth factor (PDGF-BB) was observed, nor was there an effect on fibroblast adhesion or proliferation on collagen-I. The data implicate CD151 as a facilitator of laminin-332-mediated keratinocyte functions that impact on the re-epithelialisation process intrinsic to wound healing and further suggest a potential novel role for CD151 in fibroblast migration."xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2008.04.011"xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/author | "Miyazaki K."xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/author | "Ashman L.K."xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/author | "Copeland B."xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/author | "Cowin A.J."xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/author | "Geary S.M."xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/author | "Baleato R.M."xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/pages | "2165-2175"xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/title | "The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing."xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/18534576 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18534576 |
| http://purl.uniprot.org/citations/18534576 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18534576 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRG3-mappedCitation-18534576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534576 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSK8-mappedCitation-18534576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534576 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSP0-mappedCitation-18534576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534576 |
| http://purl.uniprot.org/uniprot/#_O35566-mappedCitation-18534576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534576 |
| http://purl.uniprot.org/uniprot/#_Q921J7-mappedCitation-18534576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534576 |
| http://purl.uniprot.org/uniprot/A0A1B0GRG3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18534576 |
| http://purl.uniprot.org/uniprot/A0A1B0GSP0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18534576 |
| http://purl.uniprot.org/uniprot/A0A1B0GSK8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18534576 |
| http://purl.uniprot.org/uniprot/O35566 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18534576 |