| http://purl.uniprot.org/citations/18534987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18534987 | http://www.w3.org/2000/01/rdf-schema#comment | "Alternative 5' splice site selection allows Bcl-x to produce two isoforms with opposite effects on apoptosis. The pro-apoptotic Bcl-x(S) variant is up-regulated by ceramide and down-regulated by protein kinase C through specific cis-acting exonic elements, one of which is bound by SAP155. Splicing to the Bcl-x(S) 5' splice site is also enforced by heterogeneous nuclear ribonucleoprotein (hnRNP) F/H proteins and by Sam68 in cooperation with hnRNP A1. Here, we have characterized exon elements that influence splicing to the 5' splice site of the anti-apoptotic Bcl-x(L) isoform. Within a 86-nucleotide region (B3) located immediately upstream of the Bcl-x(L) donor site we have identified two elements (ML2 and AM2) that stimulate splicing to the Bcl-x(L) 5' splice site. SRp30c binds to these elements and can shift splicing to the 5' splice site of Bcl-x(L) in an ML2/AM2-dependent manner in vitro and in vivo. The B3 region also contains an element that represses the use of Bcl-x(L). This element is bound by U1 small nuclear ribonucleoprotein and contains two 5' splice sites that can be used when the Bcl-x(L) 5' splice site is mutated or the ML2/AM2 elements are deleted. Conversely, mutating the cryptic 5' splice sites stimulates splicing to the Bcl-x(L) site. Thus, SRp30c stimulates splicing to the downstream 5' splice site of Bcl-x(L), thereby attenuating the repressive effect of upstream U1 snRNP binding sites."xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m800353200"xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/author | "Chabot B."xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/author | "Shkreta L."xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/author | "Toutant J."xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/author | "Cloutier P."xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/author | "Revil T."xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/author | "Goekjian S."xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/pages | "21315-21324"xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/title | "Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x."xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18534987 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18534987 |
| http://purl.uniprot.org/citations/18534987 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18534987 |
| http://purl.uniprot.org/uniprot/#_Q07817-mappedCitation-18534987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534987 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3C5-mappedCitation-18534987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534987 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D2-mappedCitation-18534987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534987 |
| http://purl.uniprot.org/uniprot/#_B4DFT9-mappedCitation-18534987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534987 |
| http://purl.uniprot.org/uniprot/#_A8K3M9-mappedCitation-18534987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534987 |
| http://purl.uniprot.org/uniprot/#_Q13242-mappedCitation-18534987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534987 |
| http://purl.uniprot.org/uniprot/#_Q5TE63-mappedCitation-18534987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18534987 |
| http://purl.uniprot.org/uniprot/Q5TE63 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18534987 |
| http://purl.uniprot.org/uniprot/B4DFT9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18534987 |