| http://purl.uniprot.org/citations/18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18538592 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor E2A controls the initiation of B lymphopoiesis, which is arrested at the pre-pro-B cell stage in E2A-deficient mice. Here, we demonstrate by conditional mutagenesis that E2A is essential for the development of pro-B, pre-B, and immature B cells in the bone marrow. E2A is, however, dispensable for the generation of mature B cells and plasma cells in peripheral lymphoid organs. In contrast, germinal center B cell development is impaired in the absence of E2A despite normal AID expression and class-switch recombination. Molecular analysis revealed that E2A is required not only for initiating but also for maintaining the expression of Ebf1, Pax5, and the B cell gene program in pro-B cells. Notably, precocious Pax5 transcription from the Ikzf1 locus promotes pro-B cell development in E2A-deficient mice, demonstrating that ectopic Pax5 expression is sufficient to activate the B lymphoid transcription program in vivo in the absence of E2A."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2008.04.014"xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/author | "Kwon K."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/author | "Hutter C."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/author | "Busslinger M."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/author | "Bilic I."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/author | "Cobaleda C."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/author | "Malin S."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/pages | "751-762"xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/title | "Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development."xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18538592 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18538592 |
| http://purl.uniprot.org/citations/18538592 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18538592 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J011-mappedCitation-18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18538592 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J014-mappedCitation-18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18538592 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18538592 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC50-mappedCitation-18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18538592 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGT0-mappedCitation-18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18538592 |
| http://purl.uniprot.org/uniprot/#_A0A8Q0LUK4-mappedCitation-18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18538592 |
| http://purl.uniprot.org/uniprot/#_A0A8Q0LUK7-mappedCitation-18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18538592 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EHG2-mappedCitation-18538592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18538592 |