| http://purl.uniprot.org/citations/18541700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18541700 | http://www.w3.org/2000/01/rdf-schema#comment | "The fibronectin receptors alpha(5)beta(1) integrin and syndecan-4 cocluster in focal adhesions and coordinate cell migration by making individual contributions to the suppression of RhoA activity during matrix engagement. p190Rho-guanosine triphosphatase-activating protein (GAP) is known to inhibit RhoA during the early stages of cell spreading in an Src-dependent manner. This paper dissects the mechanisms of p190RhoGAP regulation and distinguishes the contributions of alpha(5)beta(1) integrin and syndecan-4. Matrix-induced tyrosine phosphorylation of p190RhoGAP is stimulated solely by engagement of alpha(5)beta(1) integrin and is independent of syndecan-4. Parallel engagement of syndecan-4 causes redistribution of the tyrosine-phosphorylated pool of p190RhoGAP between membrane and cytosolic fractions by a mechanism that requires direct activation of protein kinase C alpha by syndecan-4. Activation of both pathways is necessary for the efficient regulation of RhoA and, as a consequence, focal adhesion formation. Accordingly, we identify p190RhoGAP as the convergence point for adhesive signals mediated by alpha(5)beta(1) integrin and syndecan-4. This molecular mechanism explains the cooperation between extracellular matrix receptors during cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200711129"xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/author | "Settleman J."xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/author | "Bass M.D."xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/author | "Humphries M.J."xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/author | "Goryachev A.B."xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/author | "Morgan M.R."xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/author | "Roach K.A."xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/pages | "1013-1026"xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/title | "p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4."xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/18541700 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18541700 |
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