| http://purl.uniprot.org/citations/18544627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18544627 | http://www.w3.org/2000/01/rdf-schema#comment | "Base excision repair and nucleotide excision repair are vital responses to multiple types of DNA damage, including damage from tobacco exposure. Single-nucleotide polymorphisms (SNP) in these pathways may affect DNA repair capacity and therefore influence risk for cancer development. We performed a clinic-based, case-control study comprising 481 consecutive patients with confirmed pancreatic adenocarcinoma and 625 healthy controls. Allele and genotype frequencies for 16 SNPs in DNA repair genes ERCC1, XPD/ERCC2, XPC, XPF/ERCC4, OGG1, and XRCC1 were compared after adjusting for age, sex, and smoking history. Subgroup analysis by sex and smoking history was performed. Carriers of one or two XPF/ERCC4 minor alleles at R415Q had decreased risk of pancreatic adenocarcinoma compared with those who had two major alleles [odds ratio (OR), 0.59; 95% confidence interval (95% CI), 0.40-0.85]. Heavy smokers (>40 pack-years) had increased risk for cancer if they were carriers of at least one minor allele for XPD/ERCC2 at D312N (OR, 2.78; 95% CI, 1.28-6.04) or D711D (OR, 2.19; 95% CI, 1.01-4.73). No other significant differences in risk were identified. Minor alleles in DNA repair genes XPF/ERCC4 and XPD/ERCC2 were associated with altered risk for pancreatic cancer."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-5539"xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/author | "Cunningham J.M."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/author | "de Andrade M."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/author | "Petersen G.M."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/author | "McWilliams R.R."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/author | "Goode E.L."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/author | "Boardman L.A."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/author | "Bamlet W.R."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/pages | "4928-4935"xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/title | "Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk."xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/18544627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18544627 |
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| http://purl.uniprot.org/uniprot/#_A0A1W1GST9-mappedCitation-18544627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18544627 |
| http://purl.uniprot.org/uniprot/#_A0A2S1WCK5-mappedCitation-18544627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18544627 |
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| http://purl.uniprot.org/uniprot/#_B2RCY5-mappedCitation-18544627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18544627 |