| http://purl.uniprot.org/citations/18545671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18545671 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously documented a ten-fold increase in gamma(cyto)-actin expression in dystrophin-deficient skeletal muscle and hypothesized that increased gamma(cyto)-actin expression may participate in an adaptive cytoskeletal remodeling response. To explore whether increased gamma(cyto)-actin fortifies the cortical cytoskeleton in dystrophic skeletal muscle, we generated double knockout mice lacking both dystrophin and gamma(cyto)-actin specifically in skeletal muscle (ms-DKO). Surprisingly, dystrophin-deficient mdx and ms-DKO mice presented with comparable levels of myofiber necrosis, membrane instability, and deficits in muscle function. The lack of an exacerbated phenotype in ms-DKO mice suggests gamma(cyto)-actin and dystrophin function in a common pathway. Finally, because both mdx and ms-DKO skeletal muscle showed similar levels of utrophin expression and presented with identical dystrophies, we conclude utrophin can partially compensate for the loss of dystrophin independent of a gamma(cyto)-actin-utrophin interaction."xsd:string |
| http://purl.uniprot.org/citations/18545671 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0002419"xsd:string |
| http://purl.uniprot.org/citations/18545671 | http://purl.uniprot.org/core/author | "Ervasti J.M."xsd:string |
| http://purl.uniprot.org/citations/18545671 | http://purl.uniprot.org/core/author | "Lowe D.A."xsd:string |
| http://purl.uniprot.org/citations/18545671 | http://purl.uniprot.org/core/author | "Prins K.W."xsd:string |
| http://purl.uniprot.org/citations/18545671 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18545671 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/18545671 | http://purl.uniprot.org/core/pages | "e2419"xsd:string |
| http://purl.uniprot.org/citations/18545671 | http://purl.uniprot.org/core/title | "Skeletal muscle-specific ablation of gamma(cyto)-actin does not exacerbate the mdx phenotype."xsd:string |
| http://purl.uniprot.org/citations/18545671 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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