| http://purl.uniprot.org/citations/18546269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18546269 | http://www.w3.org/2000/01/rdf-schema#comment | "The secreted mitogen vascular endothelial growth factor, VEGF, plays a pivotal role in angiogenesis. Hypoxia, inactivation of p53 and oncogenic K-Ras induce VEGF expression. Other factors such as p73 may also affect VEGF levels. Curiously, p73 may also regulate angiogenesis by affecting the expression of the pigment epithelium-derived factor, PEDF. Additionally, VEGF might harbor additional functions through the activation of E2F transcription factors. Recently, a new VEGF variant formed by alternative splicing, VEGF(165)b, has been described as exerting anti-angiogenic activity. We study here whether p73 isoforms levels -TAp73 and DeltaTAp73- and p53 and K-Ras status affect the expression of the above-mentioned angiogenesis-related genes (through the correlation between their expressions), the prognostic value of VEGF(165)b and PEDF and the correlation between VEGF and E2F-1 levels. Tumor and normal tissue of 112 colorectal cancer patients was analyzed to evaluate: (i) levels of TAp73, DeltaTAp73, VEGF, VEGF(165)b, PEDF and E2F-1 by quantitative real-time RT-PCR, (ii) p53 status by immunohistochemistry and (iii) mutations in the first exon of K-Ras by PCR-SSCP. Tumor characteristics were examined in each patient. Associations were observed between: (i) specific p73 isoforms and VEGF and VEGF(165)b expression; (ii) DeltaEx2p73 variant and downregulation of PEDF; (iii) VEGF and PEDF expression; (iv) inactive p53 and VEGF(165)b levels; (v) oncogenic K-Ras and PEDF downregulation; (vi) E2F-1 and VEGF expressions; (vii) VEGF(165)b downregulation and poor prognosis parameters of tumors. We conclude that the levels of p73 isoforms could affect the expression of VEGF, VEGF(165)b and PEDF. This scenario becomes complicated because a feedback between VEGF and PEDF may exist. VEGF may activate the E2F-1 factor. Mutations in K-Ras could negatively regulate PEDF expression. p53 inactivation might result in compensatory mechanisms such as over-expression of VEGF(165)b. Our data support the role of VEGF(165)b as a tumor suppressor factor in colorectal carcinogenesis and its possible prognosis value."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.23619"xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Dominguez G."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Sanchez A."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Pena C."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Diaz R."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Espinosa P."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Garcia V."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Garcia J.M."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Silva J."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Bonilla F."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Yuste R."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/author | "Lorenzo Y."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/pages | "1060-1067"xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/title | "p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis."xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/18546269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18546269 |
| http://purl.uniprot.org/citations/18546269 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18546269 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFW9-mappedCitation-18546269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18546269 |
| http://purl.uniprot.org/uniprot/#_B7Z3B4-mappedCitation-18546269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18546269 |
| http://purl.uniprot.org/uniprot/#_O15350-mappedCitation-18546269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18546269 |
| http://purl.uniprot.org/uniprot/#_Q8WXG0-mappedCitation-18546269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18546269 |