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| http://purl.uniprot.org/citations/18550052 | http://www.w3.org/2000/01/rdf-schema#comment | "C6 glioma cells were treated with clinically relevant concentrations of valproic acid (0.5 or 1.0 mM) for 1-7 days and RT-PCR used to examine expression of the melatonin MT(1) receptor and selected epigenetic modulators. Valproic acid caused significant time-dependent changes in the mRNA expression of the melatonin MT(1) receptor, histone deacetylase (HDAC) 1, 2 and 3, and methyl CpG binding protein 2 (MeCP2). A structurally distinct HDAC inhibitor, trichostatin A, also caused a significant concentration-dependent induction of melatonin MT(1) receptor mRNA expression, suggesting involvement of an epigenetic mechanism. The ability of clinical concentrations of valproic acid to significantly alter melatonin MT(1) receptor expression, suggests a role for this receptor in the diverse neuropharmacological and oncostatic effects of this agent."xsd:string |
| http://purl.uniprot.org/citations/18550052 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejphar.2008.04.058"xsd:string |
| http://purl.uniprot.org/citations/18550052 | http://purl.uniprot.org/core/author | "Kim B."xsd:string |
| http://purl.uniprot.org/citations/18550052 | http://purl.uniprot.org/core/author | "Niles L.P."xsd:string |
| http://purl.uniprot.org/citations/18550052 | http://purl.uniprot.org/core/author | "Jawed S."xsd:string |
| http://purl.uniprot.org/citations/18550052 | http://purl.uniprot.org/core/author | "Rincon Castro L.M."xsd:string |
| http://purl.uniprot.org/citations/18550052 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18550052 | http://purl.uniprot.org/core/name | "Eur J Pharmacol"xsd:string |
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| http://purl.uniprot.org/citations/18550052 | http://purl.uniprot.org/core/title | "Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells."xsd:string |
| http://purl.uniprot.org/citations/18550052 | http://purl.uniprot.org/core/volume | "589"xsd:string |
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