| http://purl.uniprot.org/citations/18552212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18552212 | http://www.w3.org/2000/01/rdf-schema#comment | "The terminal differentiation of B cells into antibody-secreting plasma cells is tightly regulated by a complex network of transcription factors. Here we evaluated the role of the Ets factor Spi-B during terminal differentiation of human B cells. All mature tonsil and peripheral blood B-cell subsets expressed Spi-B, with the exception of plasma cells. Overexpression of Spi-B in CD19(+) B cells inhibited, similar to the known inhibitor BCL-6, the expression of plasma cell-associated surface markers and transcription factors as well as immunoglobulin production, ie, in vitro plasma cell differentiation. The arrest in B-cell differentiation enforced by Spi-B was independent of the transactivation domain, but dependent on the Ets-domain. By chromatin immunoprecipitation and assays using an inducible Spi-B construct BLIMP1 and XBP-1 were identified as direct target genes of Spi-B mediated repression. We propose a novel role for Spi-B in maintenance of germinal center and memory B cells by direct repression of major plasma cell factors and thereby plasma cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-01-136440"xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/author | "Nagasawa M."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/author | "Spits H."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/author | "Blom B."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/author | "Schotte R."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/author | "Diehl S.A."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/author | "Uittenbogaart C.H."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/author | "Scheeren F.A."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/author | "Schmidlin H."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/pages | "1804-1812"xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/title | "Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression."xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18552212 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18552212 |
| http://purl.uniprot.org/citations/18552212 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18552212 |
| http://purl.uniprot.org/uniprot/#_A1YZ20-mappedCitation-18552212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18552212 |
| http://purl.uniprot.org/uniprot/#_A0A3B3IU23-mappedCitation-18552212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18552212 |
| http://purl.uniprot.org/uniprot/#_A8K0J1-mappedCitation-18552212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18552212 |
| http://purl.uniprot.org/uniprot/#_B4DW27-mappedCitation-18552212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18552212 |
| http://purl.uniprot.org/uniprot/#_A8K823-mappedCitation-18552212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18552212 |
| http://purl.uniprot.org/uniprot/#_Q01892-mappedCitation-18552212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18552212 |
| http://purl.uniprot.org/uniprot/#_O75626-mappedCitation-18552212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18552212 |