DESCRIBE <http://purl.uniprot.org/citations/18552466>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18552466	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18552466	http://www.w3.org/2000/01/rdf-schema#comment	" Background Alpha-actinin-4 is an actin filament crosslinking protein that interacts with intercellular adhesion molecules. Recent animal studies suggested that alpha-actinin-4 is an essential component of the glomerular filtration barrier. However, little is known about its expression in human diabetic nephropathy (DN). Methods Renal biopsy tissues were obtained from 17 patients with DN. We determined the mRNA and protein expression levels of alpha-actinin-4 by in situ hybridization and immunohistochemistry. The histopathological severity of DN was classified into two groups: mild and moderate mesangial expansion groups. We also measured urinary protein excretion and creatinine clearance. Results Podocytes were positively stained for alpha-actinin-4 mRNA and protein. In the glomeruli, the percentage of cells positive for alpha-actinin-4 mRNA was significantly lower in moderate mesangial expansion group than in mild mesangial expansion group and control. The percentage of immunohistochemically positive area for alpha-actinin-4 protein in moderate mesangial expansion group was significantly lower than in mild mesangial expansion group and control. The percentage of cells positive for alpha-actinin-4 mRNA and area positive for the protein correlated inversely with severity of proteinuria. Conclusion Our results suggest that low expression levels of alpha-actinin-4 mRNA and protein are linked to the progression of glomerulopathy and proteinuria in human DN."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.org/dc/terms/identifier	"doi:10.2169/internalmedicine.47.0352"xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Kobayashi T."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Kimura M."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Kato M."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Yamamoto N."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Abe M."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Kobayashi K."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Suzuki D."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Toyoda M."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Miyauchi M."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/author	"Umezono T."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/date	"2008"xsd:gYear
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/name	"Intern Med"xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/pages	"1099-1106"xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/title	"Expression of alpha-actinin-4 in human diabetic nephropathy."xsd:string
http://purl.uniprot.org/citations/18552466	http://purl.uniprot.org/core/volume	"47"xsd:string
http://purl.uniprot.org/citations/18552466	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18552466
http://purl.uniprot.org/citations/18552466	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18552466
http://purl.uniprot.org/uniprot/#_A0A0S2Z3X3-mappedCitation-18552466	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18552466
http://purl.uniprot.org/uniprot/#_A0A0S2Z3C0-mappedCitation-18552466	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18552466
http://purl.uniprot.org/uniprot/#_A0A0S2Z3G1-mappedCitation-18552466	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18552466
http://purl.uniprot.org/uniprot/#_A0A0S2Z3G9-mappedCitation-18552466	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18552466
http://purl.uniprot.org/uniprot/#_B4E337-mappedCitation-18552466	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18552466