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| http://purl.uniprot.org/citations/18555587 | http://www.w3.org/2000/01/rdf-schema#comment | "Adiponectin, an adipocyte-derived cytokine, affects a number of physiological processes, including immune function and inflammation. We investigated whether globular adiponectin (gAd) affects the expression of inflammation-related genes in murine macrophages (RAW264 cells). DNA microarray analysis indicated that granulocyte colony-stimulating factor (G-CSF) showed the largest increase in expression in gAd-stimulated RAW264 cells. The gAd-induced secretion of G-CSF increased in a time- and dose-dependent manner. U0126 (MEK1/2 inhibitor) and PD98059 (MEK1 inhibitor) reduced the gAd-induced G-CSF mRNA expression and G-CSF protein production. gAd induced the phosphorylation of MEK1/2 and ERK1/2 in RAW264 cells. In addition, the gAd-induced phosphorylation of MEK1/2 and ERK1/2 was dramatically reduced by PD98059 and U0126, respectively. Collectively, these results suggest that MEK1/2-ERK1/2 signaling is involved in the adiponectin-induced secretion of G-CSF."xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2008.05.002"xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/author | "Yamashita Y."xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/author | "Akifusa S."xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/author | "Yamaguchi N."xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/author | "Kamio N."xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/pages | "20-25"xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/title | "Induction of granulocyte colony-stimulating factor by globular adiponectin via the MEK-ERK pathway."xsd:string |
| http://purl.uniprot.org/citations/18555587 | http://purl.uniprot.org/core/volume | "292"xsd:string |
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