| http://purl.uniprot.org/citations/18559420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18559420 | http://www.w3.org/2000/01/rdf-schema#comment | "The Sry-related high-mobility-group box transcription factor Sox9 recruits the redundant L-Sox5 and Sox6 proteins to effect chondrogenesis, but the mode of action of the trio remains unclear. We identify here a highly conserved 359-bp sequence 10 kb upstream of the Agc1 gene for aggrecan, a most essential cartilage proteoglycan and key marker of chondrocyte differentiation. This sequence directs expression of a minimal promoter in both embryonic and adult cartilage in transgenic mice, in a manner that matches Agc1 expression. The chondrogenic trio is required and sufficient to mediate the activity of this enhancer. It acts directly, Sox9 binding to a critical cis-acting element and L-Sox5/Sox6 binding to three additional elements, which are cooperatively needed. Upon binding to their specific sites, L-Sox5/Sox6 increases the efficiency of Sox9 binding to its own recognition site and thereby robustly potentiates the ability of Sox9 to activate the enhancer. L-Sox5/Sox6 similarly secures Sox9 binding to Col2a1 (encoding collagen-2) and other cartilage-specific enhancers. This study thus uncovers critical cis-acting elements and transcription factors driving Agc1 expression in cartilage and increases understanding of the mode of action of the chondrogenic Sox trio."xsd:string |
| http://purl.uniprot.org/citations/18559420 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00695-08"xsd:string |
| http://purl.uniprot.org/citations/18559420 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/18559420 | http://purl.uniprot.org/core/author | "Lefebvre V."xsd:string |
| http://purl.uniprot.org/citations/18559420 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18559420 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18559420 | http://purl.uniprot.org/core/pages | "4999-5013"xsd:string |
| http://purl.uniprot.org/citations/18559420 | http://purl.uniprot.org/core/title | "L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer."xsd:string |
| http://purl.uniprot.org/citations/18559420 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0U1RNH0-mappedCitation-18559420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559420 |
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