| http://purl.uniprot.org/citations/18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18559483 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoreplicating cells undergo multiple rounds of DNA replication leading to polyploidy or polyteny. Oscillation of Cyclin E (CycE)-dependent kinase activity is the main driving force in Drosophila endocycles. High levels of CycE-Cdk2 activity trigger S phase, while down-regulation of CycE-Cdk2 activity is crucial to allow licensing of replication origins. In mitotic cells relicensing in S phase is prevented by Geminin. Here we show that Geminin protein oscillates in endoreplicating salivary glands of Drosophila. Geminin levels are high in S phase, but drop once DNA replication has been completed. DNA licensing is coupled to mitosis through the action of the anaphase-promoting complex/cyclosome (APC/C). We demonstrate that, even though endoreplicating cells never enter mitosis, APC/C activity is required in endoreplicating cells to mediate Geminin oscillation. Down-regulation of APC/C activity results in stabilization of Geminin protein and blocks endocycle progression. Geminin is only abundant in cells with high CycE-Cdk2 activity, suggesting that APC/C-Fzr activity is periodically inhibited by CycE-Cdk2, to prevent relicensing in S-phase cells."xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.469108"xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/author | "Sprenger F."xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/author | "Lehner C."xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/author | "Rottig C."xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/author | "Querings S."xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/author | "Zielke N."xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/pages | "1690-1703"xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/title | "The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles."xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/18559483 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18559483 |
| http://purl.uniprot.org/citations/18559483 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18559483 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI54-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHG1-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGM3-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_A4V0R4-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_E1JIR3-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_M9NFR3-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_O18402-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_O96679-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_P14785-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |
| http://purl.uniprot.org/uniprot/#_Q868I9-mappedCitation-18559483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18559483 |