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http://purl.uniprot.org/citations/18565258http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18565258http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To study the contribution of the CD14 gene to the pathogenesis of rheumatoid arthritis (RA) in Japanese patients.

Methods

CD14 genotyping was carried out at the -159C/T dimorphic site in 97 RA patients and 104 normal subjects by the PCR-RFLP (restriction fragment length polymorphism)

Method

HLA-DRB1 genotyping was performed by the PCR-SSCP (sequence specific conformational polymorphism) method.

Results

The -159C/T dimorphism is not associated with whole RA or with female RA, and the results were compatible with a previous report from Germany. The -159C/T dimorphism was not associated with rheumatoid factor (RF)-positive RA, although the -159T allele tended to be associated with RF in the German report. The -159C/T dimorphism showed no association even in RA patients with the RA-susceptibility HLA-DRB1*0405. The -159T allele was prevalent in Japanese controls.

Conclusion

The CD14 gene is very unlikely to be genetically involved in the pathogenesis of Japanese RA."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/author"Kuwata S."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/author"Kobayashi N."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/author"Mori M."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/author"Takeuchi F."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/author"Murayama T."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/author"Matsuta K."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/author"Kawasugi K."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/author"Nakaue N."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/name"Clin Exp Rheumatol"xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/pages"337-339"xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/title"Genetic contribution of the CD14 -159C/T dimorphism in the promoter region in Japanese RA."xsd:string
http://purl.uniprot.org/citations/18565258http://purl.uniprot.org/core/volume"26"xsd:string
http://purl.uniprot.org/citations/18565258http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18565258
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