| http://purl.uniprot.org/citations/18566290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18566290 | http://www.w3.org/2000/01/rdf-schema#comment | "A central question in the study of cell proliferation is, what controls cell-cycle transitions? Although the accumulation of mitotic cyclins drives the transition from the G2 phase to the M phase in embryonic cells, the trigger for mitotic entry in somatic cells remains unknown. We report that the synergistic action of Bora and the kinase Aurora A (Aur-A) controls the G2-M transition. Bora accumulates in the G2 phase and promotes Aur-A-mediated activation of Polo-like kinase 1 (Plk1), leading to the activation of cyclin-dependent kinase 1 and mitotic entry. Mechanistically, Bora interacts with Plk1 and controls the accessibility of its activation loop for phosphorylation and activation by Aur-A. Thus, Bora and Aur-A control mitotic entry, which provides a mechanism for one of the most important yet ill-defined events in the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1157425"xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/author | "Fang G."xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/author | "Yates J.R."xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/author | "Jang C.Y."xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/author | "Coppinger J.A."xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/author | "Seki A."xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/pages | "1655-1658"xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/title | "Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry."xsd:string |
| http://purl.uniprot.org/citations/18566290 | http://purl.uniprot.org/core/volume | "320"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A087WV86-mappedCitation-18566290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18566290 |
| http://purl.uniprot.org/uniprot/#_Q14203-mappedCitation-18566290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18566290 |
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| http://purl.uniprot.org/uniprot/#_B4DUR2-mappedCitation-18566290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18566290 |
| http://purl.uniprot.org/uniprot/#_B4DX16-mappedCitation-18566290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18566290 |
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