| http://purl.uniprot.org/citations/18566588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18566588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18566588 | http://www.w3.org/2000/01/rdf-schema#comment | "The function of the Ets-1 transcription factor is regulated by two regions that flank its DNA-binding domain. A previously established mechanism for auto-inhibition of monomeric Ets-1 on DNA response elements with a single ETS-binding site, however, has not been observed for the stromelysin-1 promoter containing two palindromic ETS-binding sites. We present the structure of Ets-1 on this promoter element, revealing a ternary complex in which protein homo-dimerization is mediated by the specific arrangement of the two ETS-binding sites. In this complex, the N-terminal-flanking region is required for ternary protein-DNA assembly. Ets-1 variants, in which residues from this region are mutated, loose the ability for DNA-mediated dimerization and stromelysin-1 promoter transactivation. Thus, our data unravel the molecular basis for relief of auto-inhibition and the ability of Ets-1 to function as a facultative dimeric transcription factor on this site. Our findings may also explain previous data of Ets-1 function in the context of heterologous transcription factors, thus providing a molecular model that could also be valid for Ets-1 regulation by hetero-oligomeric assembly."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.117"xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.117"xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Wilmanns M."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Wilmanns M."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Kachalova G.S."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Kachalova G.S."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Lamber E.P."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Lamber E.P."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Textor L.C."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Textor L.C."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Sieweke M.H."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Sieweke M.H."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Vanhille L."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/author | "Vanhille L."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/pages | "2006-2017"xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/pages | "2006-2017"xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/title | "Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization."xsd:string |
| http://purl.uniprot.org/citations/18566588 | http://purl.uniprot.org/core/title | "Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization."xsd:string |