| http://purl.uniprot.org/citations/18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18570919 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitosis is a series of events leading to division of a cell by the process known as cytokinesis. Protein regulating cytokinesis 1 (PRC1) is a CDK substrate that associates with the mitotic spindle and functions in microtubule bundling. Previous studies revealed that loss of PRC1 is associated with chromosomal mis-segregation and atypical chromosome alignment. HSF2 is a DNA binding protein that we previously showed bookmarks the hsp70i gene during mitosis, an epigenetic mechanism which allows the hsp70i gene to re-establish transcriptional competence early in G1. Another study demonstrated that HSF2-/-mouse embryonic fibroblasts (MEFs) exhibit increased numbers of multinucleated cells vs. wild-type MEFs. This suggests that HSF2 is important for proper cytokinesis, but the mechanism was unknown. Here we report the existence of a direct interaction between HSF2 and PRC1. HSF2 and PRC1 associate during mitosis and co-localize during this phase of the cell cycle. PRC1 does not interact with the related protein HSF1, indicating the specificity of the HSF2-PRC1 interaction. Intriguingly, PRC1 is associated with the hsp70i promoter during mitosis. These results provide a potential mechanistic basis for the defective cytokinesis phenotype exhibited by HSF2-/-cells, as well as suggest a potential role for PRC1 in HSF2-mediated gene bookmarking."xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2008.04.015"xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/author | "Sarge K.D."xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/author | "Murphy L.A."xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/author | "Wilkerson D.C."xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/pages | "2224-2230"xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/title | "PRC1 associates with the hsp70i promoter and interacts with HSF2 during mitosis."xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/18570919 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18570919 |
| http://purl.uniprot.org/citations/18570919 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18570919 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P851-mappedCitation-18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18570919 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P8F8-mappedCitation-18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18570919 |
| http://purl.uniprot.org/uniprot/#_G3UWQ7-mappedCitation-18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18570919 |
| http://purl.uniprot.org/uniprot/#_G3UXT4-mappedCitation-18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18570919 |
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| http://purl.uniprot.org/uniprot/#_G3UYX6-mappedCitation-18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18570919 |
| http://purl.uniprot.org/uniprot/#_G3UYZ3-mappedCitation-18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18570919 |
| http://purl.uniprot.org/uniprot/#_G3UXB1-mappedCitation-18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18570919 |
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| http://purl.uniprot.org/uniprot/#_G3XA79-mappedCitation-18570919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18570919 |