| http://purl.uniprot.org/citations/18577580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18577580 | http://www.w3.org/2000/01/rdf-schema#comment | "Keratins 8 and 18 (collectively referred to as K8/K18) are the major components of intermediate filaments of simple epithelial cells. Recent studies have revealed the function of K8/K18 in apoptosis modulation. Here, we show that eIF3k, originally identified as the smallest subunit of eukaryotic translation initiation factor 3 (eIF3) complexes, also localizes to keratin intermediate filaments and physically associates with K18 in epithelial cells. Upon induction of apoptosis, eIF3k colocalizes with K8/K18 in the insoluble cytoplasmic inclusions. Depletion of endogenous eIF3k de-sensitizes simple epithelial cells to various types of apoptosis through a K8/K18-dependent mechanism and promotes the retention of active caspase 3 in cytoplasmic inclusions by increasing its binding to keratins. Consequently, the cleavage of caspase cytosolic and nuclear substrates, such as ICAD and PARP, respectively, is reduced in eIF3k-depleted cells. This study not only reveals the existence of eIF3k in a subcellular compartment other than the eIF3 complex, but also identifies an apoptosis-promoting function of eIF3k in simple epithelial cells by relieving the caspase-sequestration effect of K8/K18, thereby increasing the availability of caspases to their non-keratin-residing substrates."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.021394"xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/author | "Inagaki M."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/author | "Lin Y.M."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/author | "Wu Y.C."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/author | "Chen Y.R."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/author | "Wang W.J."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/author | "Inoko A."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/author | "Lin J.R."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/pages | "2382-2393"xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/title | "eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions."xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/18577580 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18577580 |
| http://purl.uniprot.org/citations/18577580 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18577580 |
| http://purl.uniprot.org/uniprot/#_A0A087WVB9-mappedCitation-18577580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18577580 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ59-mappedCitation-18577580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18577580 |
| http://purl.uniprot.org/uniprot/#_B4DVD7-mappedCitation-18577580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18577580 |
| http://purl.uniprot.org/uniprot/#_B2RA03-mappedCitation-18577580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18577580 |
| http://purl.uniprot.org/uniprot/#_B4DQ48-mappedCitation-18577580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18577580 |
| http://purl.uniprot.org/uniprot/#_K7ERF1-mappedCitation-18577580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18577580 |
| http://purl.uniprot.org/uniprot/#_Q3TY56-mappedCitation-18577580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18577580 |