| http://purl.uniprot.org/citations/18578535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18578535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18578535 | http://www.w3.org/2000/01/rdf-schema#comment | "Monacolin K is a secondary metabolite synthesized by polyketide synthases (PKS) from Monascus, and it has the same structure as lovastatin, which is mainly produced by Aspergillus terreus. In the present study, a bacterial artificial chromosome (BAC) clone, mps01, was screened from the BAC library constructed from Monascus pilosus BCRC38072 genomic DNA. The putative monacolin K biosynthetic gene cluster was found within a 42 kb region in the mps01 clone. The deduced amino acid sequences encoded by the nine genes designated as mokA-mokI, which share over 54% similarity with the lovastatin biosynthetic gene cluster in A. terreus, were assumed to be involved in monacolin K biosynthesis. A gene disruption construct designed to replace the central part of mokA, a polyketide synthase gene, in wild-type M. pilosus BCRC38072 with a hygromycin B resistance gene through homologous recombination, resulted in a mokA-disrupted strain. The disruptant did not produce monacolin K, indicating that mokA encoded the PKS responsible for monacolin K biosynthesis in M. pilosus BCRC38072."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.org/dc/terms/identifier | "doi:10.1021/jf800595k"xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.org/dc/terms/identifier | "doi:10.1021/jf800595k"xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Wang C.L."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Wang C.L."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Wu W.J."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Wu W.J."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Liaw L.L."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Liaw L.L."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Chen Y.P."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Chen Y.P."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Tseng C.P."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Tseng C.P."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Yuan G.F."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Yuan G.F."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Chen I.C."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Chen I.C."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Wu M.D."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/author | "Wu M.D."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/name | "J. Agric. Food Chem."xsd:string |
| http://purl.uniprot.org/citations/18578535 | http://purl.uniprot.org/core/name | "J. Agric. Food Chem."xsd:string |