| http://purl.uniprot.org/citations/18583960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18583960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18583960 | http://www.w3.org/2000/01/rdf-schema#comment | "TANK-binding kinase 1 (TBK1) is of central importance for the induction of type-I interferon (IFN) in response to pathogens. We identified the DEAD-box helicase DDX3X as an interaction partner of TBK1. TBK1 and DDX3X acted synergistically in their ability to stimulate the IFN promoter, whereas RNAi-mediated reduction of DDX3X expression led to an impairment of IFN production. Chromatin immunoprecipitation indicated that DDX3X is recruited to the IFN promoter upon infection with Listeria monocytogenes, suggesting a transcriptional mechanism of action. DDX3X was found to be a TBK1 substrate in vitro and in vivo. Phosphorylation-deficient mutants of DDX3X failed to synergize with TBK1 in their ability to stimulate the IFN promoter. Overall, our data imply that DDX3X is a critical effector of TBK1 that is necessary for type I IFN induction."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.126"xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.126"xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Soulat D."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Soulat D."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Decker T."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Decker T."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Hantschel O."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Hantschel O."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Burckstummer T."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Burckstummer T."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Bauch A."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Bauch A."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Goncalves A."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Goncalves A."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Stefanovic A."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Stefanovic A."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Westermayer S."xsd:string |
| http://purl.uniprot.org/citations/18583960 | http://purl.uniprot.org/core/author | "Westermayer S."xsd:string |