| http://purl.uniprot.org/citations/18585707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18585707 | http://www.w3.org/2000/01/rdf-schema#comment | "Latent transforming growth factor (TGF)-beta binding proteins are extracellular matrix (ECM) proteins involved in the regulation of TGF-beta sequestration and activation. In this study, we have identified binding domains in LTBP-4, which mediate matrix targeting and cell adhesion. LTBP-4 was found to possess heparin binding activity, especially in its N-terminal region. The C-terminal domain of LTBP-4 supported fibroblast adhesion, a property reduced by soluble heparin. In addition, we found that LTBP-4 binds directly to fibronectin (FN), which was indispensable for the matrix assembly of LTBP-4. The FN binding sites were also located in the N-terminal region. Interestingly, heparin was able to reduce the binding of LTBP-4 to FN. In fibroblast cultures, LTBP-4 colocalized first with FN and subsequently with fibrillin-1, pointing to a role for FN in the early assembly of LTBP-4. In FN -/-fibroblasts, LTBP-mediated ECM targeting was disturbed, resulting in increased TGF-beta activity. These results revealed new molecular interactions which are evidently important for the ECM targeting, but which also are evidence of novel functions for LTBP-4 as an adhesion molecule."xsd:string |
| http://purl.uniprot.org/citations/18585707 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2008.05.010"xsd:string |
| http://purl.uniprot.org/citations/18585707 | http://purl.uniprot.org/core/author | "Koli K."xsd:string |
| http://purl.uniprot.org/citations/18585707 | http://purl.uniprot.org/core/author | "Keski-Oja J."xsd:string |
| http://purl.uniprot.org/citations/18585707 | http://purl.uniprot.org/core/author | "Kantola A.K."xsd:string |
| http://purl.uniprot.org/citations/18585707 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18585707 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/18585707 | http://purl.uniprot.org/core/pages | "2488-2500"xsd:string |
| http://purl.uniprot.org/citations/18585707 | http://purl.uniprot.org/core/title | "Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/18585707 | http://purl.uniprot.org/core/volume | "314"xsd:string |
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