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http://purl.uniprot.org/citations/18586679http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18586679http://www.w3.org/2000/01/rdf-schema#comment"Interleukin-3 (IL-3) regulates cell growth by affecting various processes such as cell death, survival, and proliferation. Cues from the external environment are sensed by surface receptors, and complex signaling mechanisms arise within the cells, leading to specific functional outcomes. In this study, we demonstrate that the cytokine IL-3 induces the activation of the Ca(2+)-dependent phosphatase, calcineurin (Cn). Furthermore Cn dephosphorylates Gab2, resulting in c-fos activation and cell proliferation. We also report that there is a direct interaction between Cn and Gab2 upon IL-3 stimulation, and Akt can regulate this interaction."xsd:string
http://purl.uniprot.org/citations/18586679http://purl.org/dc/terms/identifier"doi:10.1074/jbc.c800087200"xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/author"Burakoff S.J."xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/author"Baksh S."xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/author"Pratt J.C."xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/author"Pyarajan S."xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/author"Matejovic G."xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/name"J Biol Chem"xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/pages"23505-23509"xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/title"Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction."xsd:string
http://purl.uniprot.org/citations/18586679http://purl.uniprot.org/core/volume"283"xsd:string
http://purl.uniprot.org/citations/18586679http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18586679
http://purl.uniprot.org/citations/18586679http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18586679
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http://purl.uniprot.org/uniprot/#_A4FUQ9-mappedCitation-18586679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18586679
http://purl.uniprot.org/uniprot/#_Q3ZB56-mappedCitation-18586679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18586679
http://purl.uniprot.org/uniprot/#_Q3ZB57-mappedCitation-18586679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18586679
http://purl.uniprot.org/uniprot/#_Q3ZB59-mappedCitation-18586679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18586679
http://purl.uniprot.org/uniprot/#_Q4V9X0-mappedCitation-18586679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18586679
http://purl.uniprot.org/uniprot/#_P01101-mappedCitation-18586679http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18586679