| http://purl.uniprot.org/citations/18588920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18588920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18588920 | http://www.w3.org/2000/01/rdf-schema#comment | "Nociceptin/orphanin FQ (N/OFQ) is a heptadecapeptide, which has been identified as an endogenous ligand of the opioid receptor-like (ORL1) receptor. The present study investigated the nociceptive effect of intra-nucleus accumbens (intra-NAc) injection of OFQ, and the involvement of ERK pathway in such effect. Intra-NAc injection of OFQ (0.1, 0.5, 1 nmol) dose-dependently decreased the nociceptive thresholds on the hindpaw withdrawal response to thermal and mechanical stimulation in rats. Moreover, the intra-NAc injection of OFQ-induced decreases in HWLs were antagonized by intra-NAc injection of (Nphe(1))nociceptin(1-13)NH(2), an antagonist of ORL1 receptor, in a dose-dependent way. Furthermore, the OFQ-induced nociception could be attenuated by pretreatment with the mitogen-activated protein kinase/ERK kinase (MEK) inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(2-aminopheylthio)butadiene (U0126). Our results demonstrate that OFQ induces nociceptive effects in NAc. The effect was blocked by the antagonist (Nphe(1))nociceptin(1-13)NH(2) and attenuated by U0126, suggesting that the activation of ERK pathways is involved in the OFQ-induced nociceptive effect in the NAc of rats."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.regpep.2008.06.001"xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.regpep.2008.06.001"xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/author | "Yu L.C."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/author | "Yu L.C."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/author | "Huang J.X."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/author | "Huang J.X."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/author | "Chen L.Y."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/author | "Chen L.Y."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/name | "Regul. Pept."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/name | "Regul. Pept."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/pages | "43-47"xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/pages | "43-47"xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/title | "Involvement of ORL1 receptor and ERK kinase in the orphanin FQ-induced nociception in the nucleus accumbens of rats."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/title | "Involvement of ORL1 receptor and ERK kinase in the orphanin FQ-induced nociception in the nucleus accumbens of rats."xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/18588920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18588920 |
| http://purl.uniprot.org/citations/18588920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18588920 |
| http://purl.uniprot.org/citations/18588920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18588920 |
| http://purl.uniprot.org/citations/18588920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18588920 |