| http://purl.uniprot.org/citations/18591382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18591382 | http://www.w3.org/2000/01/rdf-schema#comment | "CD40 signaling is critical for innate and adaptive immunity against pathogens, and the cytoplasmic domain of CD40 is highly conserved both within and between species. A novel missense single nucleotide polymorphism (SNP) in the cytoplasmic domain of CD40 at position 227 (P227A) was identified, which resides on a conserved ancestral haplotype highly enriched in persons of Mexican and South American descent. Functional studies indicated that signaling via human (h) CD40-P227A stably expressed in several B-cell lines led to increased phosphorylation of c-Jun, increased secretion of the pro-inflammatory cytokines interleukin (IL)-6 and TNF-alpha, and increased Ig production, compared with wild-type hCD40. Cooperation between hCD40-P227A signaling and B-cell receptor (BCR)- or Toll-like receptor 9 (TLR9)-mediated signaling was also enhanced, resulting in elevated and synergistic production of IL-6 and Ig. We have thus identified a novel genetic variant of hCD40 with a gain-of-function immune phenotype."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-02-138925"xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/author | "Graham R.R."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/author | "Altshuler D.M."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/author | "Bishop G.A."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/author | "Gaffney P.M."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/author | "Plenge R.M."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/author | "Moser K.L."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/author | "Peters A.L."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/pages | "1863-1871"xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/title | "A novel polymorphism of the human CD40 receptor with enhanced function."xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18591382 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18591382 |
| http://purl.uniprot.org/citations/18591382 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18591382 |
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| http://purl.uniprot.org/uniprot/#_A0A0S2Z349-mappedCitation-18591382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18591382 |
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| http://purl.uniprot.org/uniprot/#_P25942-mappedCitation-18591382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18591382 |
| http://purl.uniprot.org/uniprot/#_Q59F01-mappedCitation-18591382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18591382 |
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