RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/18593586http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18593586http://www.w3.org/2000/01/rdf-schema#comment"Transforming growth factor-beta (TGF-beta) is implicated as a tumor suppressor because it eliminates cancer cells from normal tissues by inhibiting cell growth and inducing apoptosis. Although p53 tumor suppressor is required for TGF-beta-induced p21 WAF1 expression and cell growth inhibition, its role in TGF-beta-induced apoptosis remains unclear. Here, we report that TAp73alpha, which is a member of the p53 family, binds to p53-binding sites in the promoters of proapoptotic Bax and Puma to activate their transcription, and mediates TGF-beta-induced apoptosis in gastric cancer cells. Our findings reveal a novel role of TAp73alpha in the induction of apoptosis by TGF-beta in cancer cells."xsd:string
http://purl.uniprot.org/citations/18593586http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2008.06.046"xsd:string
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/author"Ito Y."xsd:string
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/author"Yamamura Y."xsd:string
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/author"Lee W.L."xsd:string
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/author"Goh M.X."xsd:string
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/pages"2663-2667"xsd:string
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/title"Role of TAp73alpha in induction of apoptosis by transforming growth factor-beta in gastric cancer cells."xsd:string
http://purl.uniprot.org/citations/18593586http://purl.uniprot.org/core/volume"582"xsd:string
http://purl.uniprot.org/citations/18593586http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18593586
http://purl.uniprot.org/citations/18593586http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18593586
http://purl.uniprot.org/uniprot/#_A0A0C4DFW9-mappedCitation-18593586http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593586
http://purl.uniprot.org/uniprot/#_B7Z3B4-mappedCitation-18593586http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593586
http://purl.uniprot.org/uniprot/#_O15350-mappedCitation-18593586http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593586
http://purl.uniprot.org/uniprot/#_Q8WXG0-mappedCitation-18593586http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593586
http://purl.uniprot.org/uniprot/O15350http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18593586
http://purl.uniprot.org/uniprot/A0A0C4DFW9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18593586
http://purl.uniprot.org/uniprot/Q8WXG0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18593586
http://purl.uniprot.org/uniprot/B7Z3B4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18593586