| http://purl.uniprot.org/citations/18593809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18593809 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and aimsIt has been demonstrated that polymorphisms within inflammation-related genes are associated with the risk of gastric carcinoma (GC) in people infected with Helicobacter pylori. Recently, polymorphisms in the gene encoding the interferon gamma receptor 1 (IFNGR1) were found to be associated with increased susceptibility to H pylori infection. We aimed to determine the association between polymorphisms in the IFNGR1 gene and development of chronic gastritis and GC.MethodsIn a case-control study including 733 controls, 213 patients with chronic gastritis and 393 patients with GC, the IFNGR1 -611*G/*A, -56*C/*T, +1004*A/*C and +1400*T/*C polymorphisms were genotyped. A second independent case-control study including 100 controls and 65 patients with GC was used for confirmation of the original results. The effect of the -56*C/*T promoter polymorphism in the level of expression of the IFNGR1 gene was evaluated by an IFNGR1 -56*C/*T allele specific luciferase reporter assay.ResultsIn patients with early onset GC (defined as being less than 40 years of age at the time of diagnosis) we found a significant over-representation of the IFNGR1 -56*T/*T homozygous genotype with an odds ratio (OR) of 4.1 (95% confidence interval (CI) 1.6 to 10.6). This result was confirmed in a second independent case-control study. In the luciferase reporter assay we observed a 10-fold increase (p<0.001) in luciferase expression associated with the IFNGR1-56*T allele.ConclusionsOur results indicate that the IFNGR1 -56C/T polymorphism is a relevant host susceptibility factor for GC development. Our data also indicate that this genetic polymorphism is functionally relevant and may be related to the early development of GC."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.org/dc/terms/identifier | "doi:10.1136/gut.2007.143578"xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Seruca R."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Suriano G."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Carneiro F."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Figueiredo C."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Pereira F."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Machado J.C."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Roviello F."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Corso G."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Moreira H."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Canedo P."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Pedrazzani C."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Barros H."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/author | "Lunet N."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/name | "Gut"xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/pages | "1504-1508"xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/title | "The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma."xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/18593809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18593809 |
| http://purl.uniprot.org/citations/18593809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18593809 |
| http://purl.uniprot.org/uniprot/#_P15260-mappedCitation-18593809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18593809 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3Y2-mappedCitation-18593809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18593809 |