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http://purl.uniprot.org/citations/18593949http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18593949http://www.w3.org/2000/01/rdf-schema#comment"Steroid receptor coactivator-3 (SRC-3)/AIB1 is a member of the p160 nuclear receptor coactivator family involved in development and cell cycle progression. We previously showed that SRC-3/AIB1 is required for prostate cancer cell proliferation and survival. Here, we reported that the elevated SRC-3/AIB1 expression is significantly correlated with human prostate cancer seminal vesicle invasion and lymph node metastasis. Furthermore, SRC-3/AIB1 is associated with increased prostate cancer cell migration and invasion. SRC-3/AIB1 is required for focal adhesion turnover and focal adhesion kinase activation. In addition, SRC-3/AIB1 directly regulates transcription of matrix metalloproteinase (MMP)-2 and MMP-13 through its coactivation of AP-1 and PEA3. Taken together, these data suggest that SRC-3/AIB1 plays an essential role in prostate cancer cell invasion and metastasis."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.org/dc/terms/identifier"doi:10.1158/0008-5472.can-08-0955"xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Cai Y."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Li R."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Yan J."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Ittmann M."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Tsai S.Y."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Tsai M.J."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Yu-Lee L.Y."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Ayala G."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/author"Erdem H."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/name"Cancer Res"xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/pages"5460-5468"xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/title"Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression."xsd:string
http://purl.uniprot.org/citations/18593949http://purl.uniprot.org/core/volume"68"xsd:string
http://purl.uniprot.org/citations/18593949http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18593949
http://purl.uniprot.org/citations/18593949http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18593949
http://purl.uniprot.org/uniprot/#_A0A059VC25-mappedCitation-18593949http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593949
http://purl.uniprot.org/uniprot/#_A8K0W8-mappedCitation-18593949http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593949
http://purl.uniprot.org/uniprot/#_B4DH13-mappedCitation-18593949http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593949
http://purl.uniprot.org/uniprot/#_A0A4P8LAY1-mappedCitation-18593949http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593949
http://purl.uniprot.org/uniprot/#_B4DYS9-mappedCitation-18593949http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593949
http://purl.uniprot.org/uniprot/#_B4DYT5-mappedCitation-18593949http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18593949