| http://purl.uniprot.org/citations/18595314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18595314 | http://www.w3.org/2000/01/rdf-schema#comment | "In yeast the Protein Kinase A (PKA) pathway can be activated by a variety of nutrients. Fermentable sugars, like glucose and sucrose, trigger a spike in the cAMP level, followed by activation of PKA and phosphorylation of target proteins causing a.o. mobilization of reserve carbohydrates, repression of stress-related genes and induction of growth-related genes. Glucose and sucrose are sensed by a G-protein coupled receptor system that activates adenylate cyclase and also activates a bypass pathway causing direct activation of PKA. Addition of other essential nutrients, like nitrogen sources or phosphate, to glucose-repressed nitrogen- or phosphate-starved cells, also triggers rapid activation of the PKA pathway. In these cases cAMP is not involved as a second messenger. Amino acids are sensed by the Gap1 transceptor, previously considered only as an amino acid transporter. Recent results indicate that the amino acid ligand has to induce a specific conformational change for signaling. The same amino acid binding site is involved in transport and signaling. Similar results have been obtained for Pho84 which acts as a transceptor for phosphate activation of the PKA pathway. Ammonium activation of the PKA pathway in nitrogen-starved cells is mediated mainly by the Mep2 transceptor, which belongs to a different class of transporter proteins. Hence, different types of sensing systems are involved in control of the yeast PKA pathway by nutrients."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.org/dc/terms/identifier | "doi:10.1556/amicr.55.2008.2.1"xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Thevelein J.M."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Verhaert P."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Versele M."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Van Zeebroeck G."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Rubio-Texeira M."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Popova Y."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Thayumanavan P."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Bonini B.M."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Castermans D."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Voordeckers K."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Vandormael P."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Louwet W."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Haesendonckx S."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Kriel J."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/author | "Schepers W."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/name | "Acta Microbiol Immunol Hung"xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/pages | "75-89"xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/title | "Novel mechanisms in nutrient activation of the yeast protein kinase A pathway."xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/18595314 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18595314 |
| http://purl.uniprot.org/citations/18595314 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18595314 |