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http://purl.uniprot.org/citations/18595682http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18595682http://www.w3.org/2000/01/rdf-schema#comment"

Background and objective

The high-affinity IgE receptor comprises a tetramer of the ligand-binding alpha chain, a signal-augmenting beta chain, and a signal-transducing gamma chain dimer on mast cells. We hypothesized that the three subsets of the FCER1 gene may play a role in the development of the aspirin-intolerant asthma (AIA) phenotype and analyzed these genetic polymorphisms in association with clinical parameters in AIA patients.

Subjects and methods

Six polymorphisms of FCER1 (FCERIA-344C>T, FCER1A-95T>C, MS4A2-109T>C, MS4A2 E237G, FCER1G-237A>G, FCER1G-54G>T) were genotyped in 126 AIA patients compared to 177 patients with aspirin-tolerant asthma (ATA) and 222 normal health controls (NC).

Results

A significant difference in the genotype frequencies of FCER1G-237A>G was detected between AIA and ATA patients (p<0.05) both in co-dominant and recessive analysis models, whereas no significant relationships were identified between the frequencies of the other five single-nucleotide polymorphisms and AIA, ATA, and NC subjects. In addition, AIA patients carrying the homozygous AA genotype of FCER1G-237A>G exhibited significantly higher total serum IgE levels than did those with the GG/AG genotype (p=0.012). AIA patients expressing the CT/TT genotype at FCERIA-344C>T showed a higher prevalence of serum IgE specific to Staphylococcal enterotoxin A than did those with the CC genotype (p=0.008).

Conclusion

The FCER1G-237A>G and FCERIA-344C>T polymorphisms may contribute to the development of AIA in a Korean population."xsd:string
http://purl.uniprot.org/citations/18595682http://purl.org/dc/terms/identifier"doi:10.1016/j.rmed.2008.03.017"xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/author"Kim S.H."xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/author"Park H.S."xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/author"Hur G.Y."xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/author"Ye Y.M."xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/author"Cho B.Y."xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/author"Palikhe N.S."xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/name"Respir Med"xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/pages"1132-1139"xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/title"Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma."xsd:string
http://purl.uniprot.org/citations/18595682http://purl.uniprot.org/core/volume"102"xsd:string
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