| http://purl.uniprot.org/citations/18596024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18596024 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of IL-1 in susceptibility to Streptococcus pneumoniae infection was studied in mice deficient in genes of the IL-1 family [i.e. IL-1alpha-/-, IL-1beta-/-, IL-1alpha/beta-/- and IL-1R antagonist (IL-1Ra)-/-mice] following intra-nasal inoculation. Intra-nasal inoculation of S. pneumoniae of IL-1beta-/- and IL-1alpha/beta-/-mice displayed significantly lower survival rates and higher nasopharyngeal and lung bacterial load as compared with control, IL-1alpha-/- and IL-1Ra-/-mice. Treatment of IL-1beta-/-mice with rIL-1beta significantly improved their survival. A significant increase in blood neutrophils was found in control, IL-1alpha-/- and IL-1Ra-/-but not in IL-1beta-/- and IL-1alpha/beta-/-mice. Local infiltrates of neutrophils and relatively preserved organ architecture were observed in the lungs of IL-1alpha-/- and control mice. However, S. pneumoniae-infected IL-1beta-/-, IL-1alpha/beta-/- and IL-1Ra-/-mice demonstrated diffuse pneumonia and tissue damage. Altogether, all three isoforms contribute to protection against S. pneumoniae; our results point to differential role of IL-1alpha and IL-1beta in the pathogenesis and control of S. pneumoniae infection and suggest that IL-1beta has a major role in resistance to primary pneumococcal infection while the role of IL-1alpha is less important."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxn071"xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Ling E."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Dagan R."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Kafka D."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Benharroch D."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Apte R.N."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Feldman G."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Voronov E."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Givon-Lavi N."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/author | "Mizrachi-Nebenzahl Y."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/pages | "1139-1146"xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/title | "Contribution of IL-1 to resistance to Streptococcus pneumoniae infection."xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/18596024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18596024 |
| http://purl.uniprot.org/citations/18596024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18596024 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVU4-mappedCitation-18596024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18596024 |
| http://purl.uniprot.org/uniprot/#_P25085-mappedCitation-18596024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18596024 |
| http://purl.uniprot.org/uniprot/#_Q3TI17-mappedCitation-18596024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18596024 |
| http://purl.uniprot.org/uniprot/#_Q3U0Y6-mappedCitation-18596024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18596024 |
| http://purl.uniprot.org/uniprot/#_Q62161-mappedCitation-18596024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18596024 |