| http://purl.uniprot.org/citations/18596236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18596236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18596236 | http://www.w3.org/2000/01/rdf-schema#comment | "The SM protein UNC-18 has been proposed to regulate several aspects of secretion, including synaptic vesicle docking, priming, and fusion. Here, we show that UNC-18 has a chaperone function in neurons, promoting anterograde transport of the plasma membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein Syntaxin-1. In unc-18 mutants, UNC-64 (Caenorhabditis elegans Syntaxin-1) accumulates in neuronal cell bodies. Colocalization studies and analysis of carbohydrate modifications both suggest that this accumulation occurs in the endoplasmic reticulum. This trafficking defect is specific for UNC-64 Syntaxin-1, because 14 other SNARE proteins and two active zone markers were unaffected. UNC-18 binds to Syntaxin through at least two mechanisms: binding to closed Syntaxin, or to the N terminus of Syntaxin. It is unclear which of these binding modes mediates UNC-18 function in neurons. The chaperone function of UNC-18 was eliminated in double mutants predicted to disrupt both modes of Syntaxin binding, but it was unaffected in single mutants. By contrast, mutations predicted to disrupt UNC-18 binding to the N terminus of Syntaxin caused significant defects in locomotion behavior and responsiveness to cholinesterase inhibitors. Collectively, these results demonstrate the UNC-18 acts as a molecular chaperone for Syntaxin transport in neurons and that the two modes of UNC-18 binding to Syntaxin are involved in different aspects of UNC-18 function."xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e08-02-0160"xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e08-02-0160"xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/author | "Kaplan J.M."xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/author | "Kaplan J.M."xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/author | "McEwen J.M."xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/author | "McEwen J.M."xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/pages | "3836-3846"xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/pages | "3836-3846"xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/title | "UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin."xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/title | "UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin."xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18596236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18596236 |
| http://purl.uniprot.org/citations/18596236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18596236 |
| http://purl.uniprot.org/citations/18596236 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18596236 |
| http://purl.uniprot.org/citations/18596236 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18596236 |
| http://purl.uniprot.org/uniprot/P34815 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18596236 |
| http://purl.uniprot.org/uniprot/O16000 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18596236 |