| http://purl.uniprot.org/citations/18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18597185 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoplasmic reticulum (ER) stress-mediated apoptosis plays an important role in the destruction of pancreatic beta-cells and contributes to the development of type 1 diabetes. The chaperone molecule, glucose-regulated proteins 78 (Grp78), is required to maintain ER function during toxic insults. In this study, we investigated the changes of Grp78 expression in different phases of streptozotocin (STZ)-affected beta-cells to explore the relationship between Grp78 and the response of beta-cells to ER stress. An insulinoma cell line (NIT-1) treated with STZ for different time periods and STZ-induced diabetic Balb/C mice at different time points were used as the model system. The level of Grp78 and C/EBP homologous protein (CHOP) mRNA were detected by real-time polymerase chain reaction and their protein by immunoblot. Apoptosis and necrosis was measured by flow cytometry. In addition, the changes of Grp78 protein in STZ-treated nondiabetic mice were also detected by immunoblot. Grp78 expression significantly increased in the early phase but decreased in the later phase of affected beta-cells, while CHOP was induced and apoptosis occurred along with the decrease of Grp78. Interestingly, the Grp78 protein of STZ-treated nondiabetic mice increased stably compared with that of the control. From the results, we can conclude that Grp78 may contribute to the response of beta-cells to ER stress, and more attention should be paid to Grp78 in the improvement of diabetes."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12192-008-0053-1"xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/author | "Peng J.L."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/author | "Zhao X.P."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/author | "Shen G.X."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/name | "Cell Stress Chaperones"xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/pages | "43-48"xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/title | "The altered expression of glucose-regulated proteins 78 in different phase of streptozotocin-affected pancreatic beta-cells."xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/18597185 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18597185 |
| http://purl.uniprot.org/citations/18597185 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18597185 |
| http://purl.uniprot.org/uniprot/#_P20029-mappedCitation-18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18597185 |
| http://purl.uniprot.org/uniprot/#_Q3TI47-mappedCitation-18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18597185 |
| http://purl.uniprot.org/uniprot/#_Q3U6V3-mappedCitation-18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18597185 |
| http://purl.uniprot.org/uniprot/#_Q3U9G2-mappedCitation-18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18597185 |
| http://purl.uniprot.org/uniprot/#_Q3UEM8-mappedCitation-18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18597185 |
| http://purl.uniprot.org/uniprot/#_Q3TKF8-mappedCitation-18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18597185 |
| http://purl.uniprot.org/uniprot/#_Q3TWF2-mappedCitation-18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18597185 |
| http://purl.uniprot.org/uniprot/#_Q3TUS2-mappedCitation-18597185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18597185 |