| http://purl.uniprot.org/citations/18598289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18598289 | http://www.w3.org/2000/01/rdf-schema#comment | "1 It has been demonstrated that nerve-evoked contractions of the rat vas deferens involve alpha(1D)-adrenoceptors. Definitive evidence for a similar alpha(1D)-adrenoceptor-mediated response in mouse vas deferens has been more difficult to obtain. In this study, we have used alpha(1D)-adrenoceptor knockout (alpha(1D)-KO) mice to aid in the pharmacological characterization. 2 Mouse whole vas deferens was stimulated with a single pulse every 5 min. Once a stable response had been obtained, vehicle or antagonist was administered cumulatively at 5-min intervals and a response to stimulation obtained 5 min later. Cumulative concentration-response curves were also obtained for noradrenaline. 3 In vas deferens from alpha(1D)-KO mice, the contractile response to low concentrations of noradrenaline and the contractile response to a single stimulus were significantly reduced as compared to wild type (WT). 4 The alpha(1D)-adrenoceptor selective antagonist, BMY 7378, produced a concentration-dependent inhibition of single pulse-evoked contractions of vas deferens from WT and alpha(1D)-KO mice. BMY 7378 was significantly less potent in inhibiting stimulation-evoked contractions in vas deferens from alpha(1D)-KO mice. 5 It is concluded that alpha(1D)-adrenoceptors mediate a component of nerve- and agonist-evoked contractions of the vas deferens of WT mice."xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1474-8673.2008.00420.x"xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/author | "McGrath J.C."xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/author | "Tsujimoto G."xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/author | "Tanoue A."xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/author | "Cleary L."xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/author | "Docherty J.R."xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/author | "Bexis S."xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/name | "Auton Autacoid Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/pages | "81-85"xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/title | "Alpha(1D)-adrenoceptors mediate nerve and agonist-evoked contractions in mouse vas deferens: evidence obtained from knockout technology."xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18598289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18598289 |
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| http://purl.uniprot.org/uniprot/#_P97714-mappedCitation-18598289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18598289 |
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| http://purl.uniprot.org/uniprot/P97714 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18598289 |