| http://purl.uniprot.org/citations/18599507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18599507 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1) is essential for adrenal development and regulates genes that specify differentiated adrenocortical function. The transcriptional coactivator beta-catenin reportedly synergizes with Sf1 to regulate a subset of these target genes; moreover, Wnt family members, signaling via beta-catenin, are also implicated in adrenocortical development. To investigate the role of beta-catenin in the adrenal cortex, we used two Sf1/Cre transgenes to inactivate conditional beta-catenin alleles. Inactivation of beta-catenin mediated by Sf1/Cre(high), a transgene expressed at high levels, caused adrenal aplasia in newborn mice. Analysis of fetal adrenal development with Sf1/Cre(high)-mediated beta-catenin inactivation showed decreased proliferation in presumptive adrenocortical precursor cells. By contrast, the Sf1/Cre(low) transgene effected a lesser degree of beta-catenin inactivation that did not affect all adrenocortical cells, permitting adrenal survival to reveal age-dependent degeneration of the cortex. These results define crucial roles for beta-catenin--presumably as part of the Wnt canonical signaling pathway--in both embryonic development of the adrenal cortex and in maintenance of the adult organ."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.021493"xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Else T."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Hammer G.D."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Parker K.L."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Kim A.C."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Lavery G.G."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Zubair M."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Bingham N.C."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Reuter A.L."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/author | "Serecky K."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/pages | "2593-2602"xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/title | "Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex."xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/18599507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18599507 |
| http://purl.uniprot.org/citations/18599507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18599507 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-18599507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18599507 |
| http://purl.uniprot.org/uniprot/#_A0A087WRU6-mappedCitation-18599507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18599507 |
| http://purl.uniprot.org/uniprot/#_E9Q9G5-mappedCitation-18599507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18599507 |
| http://purl.uniprot.org/uniprot/#_A0A087WRA8-mappedCitation-18599507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18599507 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-18599507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18599507 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-18599507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18599507 |