| http://purl.uniprot.org/citations/18599520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18599520 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivePharmacogenomics is a key component of personalized medicine. The Israel Cardiovascular Events Reduction with Vitamin E Study, a prospective placebo-controlled study, recently demonstrated that vitamin E could dramatically reduce CVD in individuals with diabetes and the haptoglobin (Hp) 2-2 genotype (40% of diabetic individuals). However, because of the large number of clinical trials that failed to demonstrate benefit from vitamin E coupled with the lack of a mechanistic explanation for why vitamin E should be beneficial only in diabetic individuals with the Hp 2-2 genotype, enthusiasm for this pharmacogenomic paradigm has been limited. In this study, we sought to provide such a mechanistic explanation based on the hypothesis that the Hp 2-2 genotype and diabetes interact to promote HDL oxidative modification and dysfunction.Research design and methodsHb and lipid peroxides were assessed in HDL isolated from diabetic individuals or mice with the Hp 1-1 or Hp 2-2 genotypes. HDL function was assessed based on its ability to promote cholesterol efflux from macrophages. A crossover placebo-controlled study in Hp 2-2 diabetic humans and in Hp 1-1 and Hp 2-2 diabetic mice assessed the ability of vitamin E to favorably modify these structural and functional parameters. RESULTS-Hb and lipid peroxides associated with HDL were increased and HDL function was impaired in Hp 2-2 diabetic individuals and mice. Vitamin E decreased oxidative modification of HDL and improved HDL function in Hp 2-2 diabetes but had no effect in Hp 1-1 diabetes.ConclusionsVitamin E significantly improves the quality of HDL in Hp 2-2 diabetic individuals."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.org/dc/terms/identifier | "doi:10.2337/db08-0450"xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Blum S."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Abassi Z."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Aviram M."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Alshiek J."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Asaf R."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Asleh R."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Kalet-Litman S."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Levy A.P."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Miller-Lotan R."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Rock W."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Milman U."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/author | "Shapira C."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/pages | "2794-2800"xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/title | "Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype."xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/18599520 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18599520 |
| http://purl.uniprot.org/citations/18599520 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18599520 |
| http://purl.uniprot.org/uniprot/#_Q3UBS3-mappedCitation-18599520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18599520 |
| http://purl.uniprot.org/uniprot/#_Q61646-mappedCitation-18599520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18599520 |
| http://purl.uniprot.org/uniprot/Q3UBS3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18599520 |