| http://purl.uniprot.org/citations/18600473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18600473 | http://www.w3.org/2000/01/rdf-schema#comment | "Effects of representative members of the transforming growth factor-beta (TGF-beta) family, TGF-beta1, activin A and BMP-2, on melanin content and expression of pigment-producing enzymes were examined in B16 melanoma cells. Treatment with TGF-beta1 or activin A but not with BMP-2 significantly decreased melanin content and expression of Tyrosinase and Tyrp-1, suggesting an inhibitory effect of TGF-beta1 and activin A on melanin synthesis. TGF-beta1 completely inhibited melanin synthesis induced by alpha-melanin stimulating hormone (alpha-MSH), whereas activin A only slightly did. As compared with parental B16 cells, the inhibitory effects of TGF-beta1 and activin A on melanin content were relative smaller in B16 F10 cells, a subline of B16 cells that contain more pigment. The present study indicates that in addition to TGF-beta, activin negatively regulates melanogenesis in the absence of alpha-MSH, but that the activity in the presence of alpha-MSH was slightly different between TGF-beta and activin."xsd:string |
| http://purl.uniprot.org/citations/18600473 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11033-008-9304-6"xsd:string |
| http://purl.uniprot.org/citations/18600473 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/18600473 | http://purl.uniprot.org/core/author | "Matsuzaki F."xsd:string |
| http://purl.uniprot.org/citations/18600473 | http://purl.uniprot.org/core/author | "Funaba M."xsd:string |
| http://purl.uniprot.org/citations/18600473 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18600473 | http://purl.uniprot.org/core/name | "Mol Biol Rep"xsd:string |
| http://purl.uniprot.org/citations/18600473 | http://purl.uniprot.org/core/pages | "1247-1250"xsd:string |
| http://purl.uniprot.org/citations/18600473 | http://purl.uniprot.org/core/title | "Regulation of melanin synthesis by the TGF-beta family in B16 melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/18600473 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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