| http://purl.uniprot.org/citations/18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18604213 | http://www.w3.org/2000/01/rdf-schema#comment | "The costimulatory molecule 4-1BB and its ligand 4-1BBL can control adaptive immunity, but here we show that their interaction also suppressed myelopoiesis. We found that 4-1BBL was expressed on hematopoietic stem cells, differentiating common myeloid progenitors and granulocyte-macrophage progenitors, and 4-1BB was inducible on activated myeloid progenitors. Steady-state numbers of granulocyte-macrophage progenitors, myeloid-lineage cells and mature dendritic cells were higher in 4-1BB- and 4-1BBL-deficient mice, indicative of a negative function, and we confirmed that result with bone marrow chimeras and in vitro, where the absence of interactions between 4-1BB and 4-1BBL led to enhanced differentiation into dendritic cell lineages. The regulatory activity was mediated by 4-1BBL, with binding by 4-1BB inhibiting differentiation of myeloid progenitors. Thus, 4-1BB and 4-1BBL have a previously unknown function in limiting myelopoiesis and the development of dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1632"xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/author | "Park Y."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/author | "So T."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/author | "Croft M."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/author | "Cheroutre H."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/author | "Kwon B.S."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/author | "Mittler R.S."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/pages | "917-926"xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/title | "Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18604213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18604213 |
| http://purl.uniprot.org/citations/18604213 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18604213 |
| http://purl.uniprot.org/uniprot/#_A2A886-mappedCitation-18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18604213 |
| http://purl.uniprot.org/uniprot/#_A2A887-mappedCitation-18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18604213 |
| http://purl.uniprot.org/uniprot/#_A2A888-mappedCitation-18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18604213 |
| http://purl.uniprot.org/uniprot/#_P41274-mappedCitation-18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18604213 |
| http://purl.uniprot.org/uniprot/#_Q3U1Z9-mappedCitation-18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18604213 |
| http://purl.uniprot.org/uniprot/#_P20334-mappedCitation-18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18604213 |
| http://purl.uniprot.org/uniprot/#_Q3TEQ6-mappedCitation-18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18604213 |
| http://purl.uniprot.org/uniprot/#_Q3U3R1-mappedCitation-18604213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18604213 |